The Effects of Moringa oleifera on Blood IL-6 Levels: A Scoping Review

Penulis

  • Muhammad Husni Fansury Nasution Universitas Malikussaleh
  • Sarah Rahmayani Siregar Universitas Malikussaleh
  • Maulana Ikhsan Universitas Malikussaleh
  • Rivhan Fauzan Universitas Malikussaleh
  • Dwi Martha Nur Aditya University of Surabaya
  • Putri Eka Sari STIKes Darussalam Lhokseumawe
  • Anis En Nabiilah Universitas Malikussaleh
  • Muhammad Khalid Mirza Universitas Malikussaleh
  • Andi Saputra Universitas Malikussaleh

DOI:

https://doi.org/10.58812/jmws.v5i08.3705

Kata Kunci:

Moringa Oleifera, Blood IL-6, Anti-Inflammatory, Scoping Review, Animal Model

Abstrak

Interleukin-6 (IL-6) is widely used as an inflammatory biomarker and has also become a therapeutic target in several inflammatory and malignant diseases. Moringa oleifera (MO) has been reported to possess anti-inflammatory activity, yet evidence regarding its effect on blood IL-6 levels remains limited. This scoping review analyzed available evidence on the effect of MO on blood IL-6 levels. The review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR). A PubMed search was conducted using the keywords ((Moringa oleifera) AND (Interleukin-6 OR IL-6)) AND (blood), covering publications from January 2006 to January 2026. Nine studies met the inclusion criteria. All studies used animal experimental models, measured IL-6 in serum using ELISA, and applied randomized placebo-controlled designs. Most studies reported a significant reduction in blood IL-6 levels after MO intervention. The preparations included aqueous extracts, ethanol extracts, polyphenol extracts, n-butanol fractions, seed powder, and beta-sitosterol isolated from n-butanol seed extract. Overall, MO may have prophylactic potential for chronic inflammatory conditions characterized by elevated blood IL-6 levels; however, standardized preparations and human studies are still needed.

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Unduhan

Diterbitkan

2026-08-05

Terbitan

Vol 5 No 08 (2026): Jurnal Multidisiplin West Science

Bagian

Artikel

Lisensi

Hak Cipta (c) 2026 Muhammad Husni Fansury Nasution, Sarah Rahmayani Siregar, Maulana Ikhsan, Rivhan Fauzan, Dwi Martha Nur Aditya, Putri Eka Sari, Anis En Nabiilah, Muhammad Khalid Mirza, Andi Saputra

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Artikel ini berlisensiCreative Commons Attribution-ShareAlike 4.0 International License.

Cara Mengutip

The Effects of Moringa oleifera on Blood IL-6 Levels: A Scoping Review. (2026). Jurnal Multidisiplin West Science, 5(08), 1599-1606. https://doi.org/10.58812/jmws.v5i08.3705